On 21 August 2021, Prof. Huan Nguyen delivered a keynote talk on “Digital Twins for Infrastructure and Smart Manufacturing” at the virtual 3rd International Conference on Automation, Mechatronics, and Robotics (ICAMEROB 2021) to discuss the digital twin technology and showcase the recent results at the London Digital Twin Research Centre on the development of Digital Twin for infrastructure and smart manufacturing. The talk fits well into the conference theme “Breakthrough Innovation, Creativity and Resilience by Embracing Change & Transformation through Research,” and attracted great attention from audience from Far East in this new Digital Twin technology.